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forodesine hydrochloride  (BioCryst Inc)

 
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    BioCryst Inc forodesine hydrochloride
    Forodesine Hydrochloride, supplied by BioCryst Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/forodesine+hydrochloride/forodesine/pm37801827-346-16-13
    Average 90 stars, based on 1 article reviews
    forodesine hydrochloride - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Clinical Proteomics:

    Article Title: Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase.
    Article Snippet: Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase

    Control:

    Article Title: Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase.
    Article Snippet: Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase

    other:

    Article Title: Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.
    Article Snippet: Purine nucleoside phosphorylase (PNP) deficiency is a rare, inherited immunodeficiency disorder in which the specific molecular defect was identified.. Clinically, a lack of PNP manifests as profound T-cell deficiency with minor or variable changes in the humoral system.. Biochemically, the absence of PNP results in an increase in plasma deoxyguanosine (dGuo) and a T-cell-specific increase in intracellular deoxyguanosine triphosphate (dGTP).

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    Article Snippet: Introduction: In the last few years, several new purine and pyrimidine nucleoside analogs have been synthesized and made available for both preclinical studies and clinical trials.. Areas covered: This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity as well as the emerging role of newer purine and pyrimidine nucleoside analogs potentially active in lymphoid and myeloid malignancies.. A literature review was conducted from the MEDLINE database PubMed for articles in English.



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    forodesine hydrochloride  (MedChemExpress)
    93
    MedChemExpress forodesine hydrochloride
    Net release or uptake of nucleosides from undifferentiated (fibroblasts) or differentiated (adipocytes) cells over 48 hours. A. Murine 3T3-L1 cells (n=6). B. Murine adipose tissue SVF-derived adipocytes (n=4). C. Representative images of mature and hypertrophic 3T3-L1 adipocytes in brightfield or stained with AdipoRed and Hoechst 33342. Images were obtained on a BioTek Cytation cell imaging multimode reader (Biotek, Winooski, VT) at 20X magnification. D. Nucleosides released over 48 hours from hypertrophic relative to mature 3T3-L1 adipocytes (n=3). All cells were cultured in the presence of nucleosidase inhibitors (10 μM pentostatin, 10 μM <t>forodesine,</t> 1 μM ABT702). Error bars show SD. *p<0.05, **p<0.01, ***p<0.001, one-sided t test vs. fibroblasts ( A, B ) or mature 3T3-L1 adipocytes ( D ).
    Forodesine Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/forodesine+hydrochloride/Forodesine+hydrochloride/pmc12742186-24-0-9
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    lko mice  (MedChemExpress)
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    Net release or uptake of nucleosides from undifferentiated (fibroblasts) or differentiated (adipocytes) cells over 48 hours. A. Murine 3T3-L1 cells (n=6). B. Murine adipose tissue SVF-derived adipocytes (n=4). C. Representative images of mature and hypertrophic 3T3-L1 adipocytes in brightfield or stained with AdipoRed and Hoechst 33342. Images were obtained on a BioTek Cytation cell imaging multimode reader (Biotek, Winooski, VT) at 20X magnification. D. Nucleosides released over 48 hours from hypertrophic relative to mature 3T3-L1 adipocytes (n=3). All cells were cultured in the presence of nucleosidase inhibitors (10 μM pentostatin, 10 μM <t>forodesine,</t> 1 μM ABT702). Error bars show SD. *p<0.05, **p<0.01, ***p<0.001, one-sided t test vs. fibroblasts ( A, B ) or mature 3T3-L1 adipocytes ( D ).
    Lko Mice, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/forodesine+hydrochloride/Forodesine+hydrochloride/pmc12328062-462-13-25
    Average 93 stars, based on 1 article reviews
    lko mice - by Bioz Stars, 2026-10
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    purine nucleoside phosphorylase inhibitor forodesine hydrochloride  (MedChemExpress)
    93
    MedChemExpress purine nucleoside phosphorylase inhibitor forodesine hydrochloride
    Effects of inhibitors of adenosine metabolism on the utilization of adenosine for ATP restoration in glucose-fed astrocytes. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose (5 mM)-containing IB without or with 30 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine <t>nucleoside</t> <t>phosphorylase</t> inhibitor <t>forodesine</t> (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (36.8 ± 1.6 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 130 ± 12 µg/well and the initial cellular LDH activity 119 ± 5 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the respective control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (t-test) between data for adenosine-free and the respective adenosine-containing incubations is indicated by # p < 0.05, ## p < 0.01and ### p < 0.001
    Purine Nucleoside Phosphorylase Inhibitor Forodesine Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    forodesine hydrochloride  (BOC Sciences)
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    BOC Sciences forodesine hydrochloride
    Effects of inhibitors of adenosine metabolism on the utilization of adenosine for ATP restoration in glucose-fed astrocytes. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose (5 mM)-containing IB without or with 30 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine <t>nucleoside</t> <t>phosphorylase</t> inhibitor <t>forodesine</t> (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (36.8 ± 1.6 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 130 ± 12 µg/well and the initial cellular LDH activity 119 ± 5 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the respective control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (t-test) between data for adenosine-free and the respective adenosine-containing incubations is indicated by # p < 0.05, ## p < 0.01and ### p < 0.001
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    forodesine hydrochloride - by Bioz Stars, 2026-10
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    forodesine hydrochloride  (BioCryst Inc)
    90
    BioCryst Inc forodesine hydrochloride
    Effects of inhibitors of adenosine metabolism on the utilization of adenosine for ATP restoration in glucose-fed astrocytes. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose (5 mM)-containing IB without or with 30 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine <t>nucleoside</t> <t>phosphorylase</t> inhibitor <t>forodesine</t> (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (36.8 ± 1.6 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 130 ± 12 µg/well and the initial cellular LDH activity 119 ± 5 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the respective control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (t-test) between data for adenosine-free and the respective adenosine-containing incubations is indicated by # p < 0.05, ## p < 0.01and ### p < 0.001
    Forodesine Hydrochloride, supplied by BioCryst Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/forodesine+hydrochloride/forodesine/pm37801827-346-16-13
    Average 90 stars, based on 1 article reviews
    forodesine hydrochloride - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Net release or uptake of nucleosides from undifferentiated (fibroblasts) or differentiated (adipocytes) cells over 48 hours. A. Murine 3T3-L1 cells (n=6). B. Murine adipose tissue SVF-derived adipocytes (n=4). C. Representative images of mature and hypertrophic 3T3-L1 adipocytes in brightfield or stained with AdipoRed and Hoechst 33342. Images were obtained on a BioTek Cytation cell imaging multimode reader (Biotek, Winooski, VT) at 20X magnification. D. Nucleosides released over 48 hours from hypertrophic relative to mature 3T3-L1 adipocytes (n=3). All cells were cultured in the presence of nucleosidase inhibitors (10 μM pentostatin, 10 μM forodesine, 1 μM ABT702). Error bars show SD. *p<0.05, **p<0.01, ***p<0.001, one-sided t test vs. fibroblasts ( A, B ) or mature 3T3-L1 adipocytes ( D ).

    Journal: American journal of physiology. Cell physiology

    Article Title: Adipose Tissue Releases Nucleosides

    doi: 10.1152/ajpcell.00695.2025

    Figure Lengend Snippet: Net release or uptake of nucleosides from undifferentiated (fibroblasts) or differentiated (adipocytes) cells over 48 hours. A. Murine 3T3-L1 cells (n=6). B. Murine adipose tissue SVF-derived adipocytes (n=4). C. Representative images of mature and hypertrophic 3T3-L1 adipocytes in brightfield or stained with AdipoRed and Hoechst 33342. Images were obtained on a BioTek Cytation cell imaging multimode reader (Biotek, Winooski, VT) at 20X magnification. D. Nucleosides released over 48 hours from hypertrophic relative to mature 3T3-L1 adipocytes (n=3). All cells were cultured in the presence of nucleosidase inhibitors (10 μM pentostatin, 10 μM forodesine, 1 μM ABT702). Error bars show SD. *p<0.05, **p<0.01, ***p<0.001, one-sided t test vs. fibroblasts ( A, B ) or mature 3T3-L1 adipocytes ( D ).

    Article Snippet: Forodesine hydrochloride (HY-16209), and rosiglitazone (HY-17386) were purchased from MedChem Express (Monmouth Junction, NJ).

    Techniques: Derivative Assay, Staining, Imaging, Cell Culture

    Effects of inhibitors of adenosine metabolism on the utilization of adenosine for ATP restoration in glucose-fed astrocytes. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose (5 mM)-containing IB without or with 30 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine nucleoside phosphorylase inhibitor forodesine (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (36.8 ± 1.6 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 130 ± 12 µg/well and the initial cellular LDH activity 119 ± 5 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the respective control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (t-test) between data for adenosine-free and the respective adenosine-containing incubations is indicated by # p < 0.05, ## p < 0.01and ### p < 0.001

    Journal: Neurochemical Research

    Article Title: ATP Restoration by ATP-Deprived Cultured Primary Astrocytes

    doi: 10.1007/s11064-024-04276-9

    Figure Lengend Snippet: Effects of inhibitors of adenosine metabolism on the utilization of adenosine for ATP restoration in glucose-fed astrocytes. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose (5 mM)-containing IB without or with 30 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine nucleoside phosphorylase inhibitor forodesine (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (36.8 ± 1.6 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 130 ± 12 µg/well and the initial cellular LDH activity 119 ± 5 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the respective control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (t-test) between data for adenosine-free and the respective adenosine-containing incubations is indicated by # p < 0.05, ## p < 0.01and ### p < 0.001

    Article Snippet: The adenosine kinase inhibitor ABT-702 and the purine nucleoside phosphorylase inhibitor forodesine hydrochloride were obtained from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Incubation, Activity Assay, Control

    Prevention of the exclusive utilization of adenosine for ATP restoration by inhibitors of adenosine metabolism. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose-free IB with 100 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine nucleoside phosphorylase inhibitor forodesine (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (37.3 ± 2.4 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 136 ± 22 µg/well and the initial cellular LDH activity was 163 ± 59 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (ANOVA) compared with the data obtained after the 60 min pre-incubation (8.1 ± 4.4 nmol/mg; indicated by the black dashed lines in panel a) is indicated by + p < 0.05 and +++ p < 0.001

    Journal: Neurochemical Research

    Article Title: ATP Restoration by ATP-Deprived Cultured Primary Astrocytes

    doi: 10.1007/s11064-024-04276-9

    Figure Lengend Snippet: Prevention of the exclusive utilization of adenosine for ATP restoration by inhibitors of adenosine metabolism. Astrocyte cultures had been preincubated for 60 min in glucose-free IB with 1 µM of BAM15 to lower the cellular ATP content before the cells were incubated in glucose-free IB with 100 µM adenosine in the absence or the presence of the adenosine kinase inhibitor ABT-702 (ABT; 10 µM), the adenosine deaminase inhibitor DCF (1 µM) and/or the purine nucleoside phosphorylase inhibitor forodesine (Foro; 10 µM). After 60 min, the cellular ATP content ( a ) and the extracellular LDH activity ( b ) were determined. The data shown are means ± SD of values obtained in three experiments performed on independently prepared cultures. The average initial ATP content of the cultures (37.3 ± 2.4 nmol/mg) is indicated by the black dotted line in panel a. The protein content of the cultures was 136 ± 22 µg/well and the initial cellular LDH activity was 163 ± 59 nmol/(min × well). The significance of differences (ANOVA) compared with the data obtained for the control incubation (absence of all inhibitors) is indicated by *** p < 0.001. The significance of differences (ANOVA) compared with the data obtained after the 60 min pre-incubation (8.1 ± 4.4 nmol/mg; indicated by the black dashed lines in panel a) is indicated by + p < 0.05 and +++ p < 0.001

    Article Snippet: The adenosine kinase inhibitor ABT-702 and the purine nucleoside phosphorylase inhibitor forodesine hydrochloride were obtained from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Incubation, Activity Assay, Control